Use este identificador para citar ou linkar para este item: http://higia.imip.org.br/handle/123456789/697
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dc.contributor.authorGuimarães, Helio P.-
dc.contributor.authorSilva, Pedro G.M. de Barros e-
dc.contributor.authorLiporace, Idelzuita L.-
dc.contributor.authorSampaio, Roney O.-
dc.contributor.authorTarasoutchi, Flávio-
dc.contributor.authorPaixão, Milena-
dc.contributor.authorHoffmann-Filho, Conrado R.-
dc.contributor.authorPatriota, Rodrigo-
dc.contributor.authorLeiria, Tiago L.L.-
dc.contributor.authorLamprea, Diana-
dc.contributor.authorPrecoma, Dalton B.-
dc.contributor.authorAtik, Fernando A.-
dc.contributor.authorSilveira, Fabio S.-
dc.contributor.authorFarias, Fabio R.-
dc.contributor.authorBarreto, Diogo O.-
dc.contributor.authorAlmeida, Adail P.-
dc.contributor.authorZilli, Alexandre C.-
dc.contributor.authorSouza Neto, João D. de-
dc.contributor.authorCavalcante, Margaret A.-
dc.contributor.authorFigueira, Fernando Augusto Marinho dos Santos-
dc.contributor.authorA. Junior, Roque-
dc.contributor.authorMoisés, Valdir A.-
dc.contributor.authorMesas, Cezar E.-
dc.contributor.authorArdito, Roberto V.-
dc.contributor.authorKalil, Paulo S.A.-
dc.contributor.authorPaiva, Maria S.M.O.-
dc.contributor.authorMaldonado, Jaime G.A.-
dc.contributor.authorLima, Carlos E.B. de-
dc.contributor.authorVieira, Ricardo D'Oliveira-
dc.contributor.authorLaranjeira, Ligia-
dc.contributor.authorKojima, Flávia-
dc.contributor.authorDamiani, Lucas-
dc.contributor.authorNakagawa, Renato H.-
dc.contributor.authorSantos, Juliana R.Y. dos-
dc.contributor.authorSampaio, Bruna S.-
dc.contributor.authorCampos, Viviane B.-
dc.contributor.authorSaraiva, Jose F.K.-
dc.contributor.authorFonseca, Francisco H.-
dc.contributor.authorPinto, Ibraim M.-
dc.contributor.authorMagalhães, Carlos C.-
dc.contributor.authorFerreira, Joao F.M.-
dc.contributor.authorLopes, Renato D.-
dc.contributor.authorPavanello, Ricardo-
dc.contributor.authorCavalcanti, Alexandre B.-
dc.contributor.authorBerwanger, Otavio-
dc.date.accessioned2022-05-31T20:15:33Z-
dc.date.available2022-05-31T20:15:33Z-
dc.date.issued2021-
dc.identifier.urihttp://higia.imip.org.br/handle/123456789/697-
dc.description.abstractThe efficacy and safety of rivaroxaban in patients with bioprosthetic mitral valves and atrial fibrillation or flutter remain uncertain. DESIGN: RIVER was an academic-led, multicenter, open-label, randomized, non-inferiority trial with blinded outcome adjudication that enrolled 1005 patients from 49 sites in Brazil. Patients with a bioprosthetic mitral valve and atrial fibrillation or flutter were randomly assigned (1:1) to rivaroxaban 20 mg once daily (15 mg in those with creatinine clearance <50 mL/min) or dose-adjusted warfarin (target international normalized ratio 2.0-30.); the follow-up period was 12 months. The primary outcome was a composite of all-cause mortality, stroke, transient ischemic attack, major bleeding, valve thrombosis, systemic embolism, or hospitalization for heart failure. Secondary outcomes included individual components of the primary composite outcome, bleeding events, and venous thromboembolism. SUMMARY: RIVER represents the largest trial specifically designed to assess the efficacy and safety of a direct oral anticoagulant in patients with bioprosthetic mitral valves and atrial fibrillation or flutter. The results of this trial can inform clinical practice and international guidelines.pt_BR
dc.language.isoen_USpt_BR
dc.subjectFibrilação Atrialpt_BR
dc.subjectEnsaio Clínicopt_BR
dc.subjectValva Mitralpt_BR
dc.subjectRivaroxabanapt_BR
dc.titleA randomized clinical trial to evaluate the efficacy and safety of rivaroxaban in patients with bioprosthetic mitral valve and atrial fibrillation or flutter: Rationale and design of the RIVER trialpt_BR
dc.higia.programArtigos científicos colaboradores IMIPpt_BR
dc.higia.tipoArtigo Científicopt_BR
dc.higia.pages9 p.pt_BR
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