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dc.contributor.authorLeonhard, Sonja E.-
dc.contributor.authorHalstead, Susan-
dc.contributor.authorLant, Suzannah B.-
dc.contributor.authorAlbuquerque, Maria de Fatima Pessoa Militão de-
dc.contributor.authorBrito, Carlos Alexandre Antunes de-
dc.contributor.authorAlbuquerque, Lívia Brito Bezerra de-
dc.contributor.authorEllul, Mark A.-
dc.contributor.authorFrança, Rafael Freitas de Oliveira-
dc.contributor.authorGourlay, Dawn-
dc.contributor.authorGriffiths, Michael J.-
dc.contributor.authorHenriques-Souza, Adélia Mariade Miranda-
dc.contributor.authorMachado, Maria Í.de Morais-
dc.contributor.authorMedialdea-Carrera, Raquel-
dc.contributor.authorMehta, Ravi-
dc.contributor.authorMelo, Roberta da Paz-
dc.contributor.authorMesquita, Solange Dornelas-
dc.contributor.authorMoreira, Álvaro José Porto-
dc.contributor.authorPena, Lindomar José-
dc.contributor.authorFerreira, Maria Lucia Brito-
dc.date.accessioned2022-06-22T15:13:02Z-
dc.date.available2022-06-22T15:13:02Z-
dc.date.issued2021-
dc.identifier.urihttp://higia.imip.org.br/handle/123456789/766-
dc.description.abstractObjective: To determine the clinical phenotype of Guillain-Barré syndrome (GBS) after Zika virus (ZIKV) infection, the anti-glycolipid antibody signature, and the role of other circulating arthropod-borne viruses, we describe a cohort of GBS patients identified during ZIKV and chikungunya virus (CHIKV) outbreaks in Northeast Brazil. Methods: We prospectively recruited GBS patients from a regional neurology center in Northeast Brazil between December 2014 and February 2017. Serum and CSF were tested for ZIKV, CHIKV, and dengue virus (DENV), by RT-PCR and antibodies, and serum was tested for GBS-associated antibodies to glycolipids. Results: Seventy-one patients were identified. Forty-eight (68%) had laboratory evidence of a recent arbovirus infection; 25 (52%) ZIKV, 8 (17%) CHIKV, 1 (2%) DENV, and 14 (29%) ZIKV and CHIKV. Most patients with a recent arbovirus infection had motor and sensory symptoms (72%), a demyelinating electrophysiological subtype (67%) and a facial palsy (58%). Patients with a recent infection with ZIKV and CHIKV had a longer hospital admission and more frequent mechanical ventilation compared to the other patients. No specific anti-glycolipid antibody signature was identified in association with arbovirus infection, although significant antibody titres to GM1, GalC, LM1, and GalNAc-GD1a were found infrequently. Conclusion: A large proportion of cases had laboratory evidence of a recent infection with ZIKV or CHIKV, and recent infection with both viruses was found in almost one third of patients. Most patients with a recent arbovirus infection had a sensorimotor, demyelinating GBS. We did not find a specific anti-glycolipid antibody signature in association with arbovirus-related GBS.pt_BR
dc.language.isoenpt_BR
dc.subjectSíndrome de Guillain-Barrépt_BR
dc.subjectZika viruspt_BR
dc.subjectVírus Chikungunyapt_BR
dc.subjectInfecções por Arboviruspt_BR
dc.titleGuillain-Barré syndrome during the Zika virus outbreak in Northeast Brazil: An observational cohort studypt_BR
dc.higia.programArtigos científicos colaboradores IMIPpt_BR
dc.higia.tipoArtigo Científicopt_BR
dc.higia.pages8 p.pt_BR
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