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dc.contributor.authorSilva, Ronaldo Celerino da-
dc.contributor.authorAlves, Neyla Maria Pereira-
dc.contributor.authorSilva, Maria Luiza Gondim-
dc.contributor.authorAgrelli, Almerinda-
dc.contributor.authorCoelho, Antonio Victor Campos-
dc.contributor.authorGuimarães, Rafael Lima-
dc.contributor.authorAlencar, Luiz Cláudio Arraes de-
dc.contributor.authorCrovella, Sergio-
dc.contributor.authorBrandão, Lucas André Cavalcanti-
dc.date.accessioned2022-07-01T15:41:01Z-
dc.date.available2022-07-01T15:41:01Z-
dc.date.issued2021-
dc.identifier.urihttp://higia.imip.org.br/handle/123456789/805-
dc.description.abstractBackground: Antiretroviral therapy (ART) is an important hallmark of HIV-1 treatment, enabling viral load suppression to undetectable levels and CD4+ T-cell recovery. However, some individuals do not recover the CD4+ T-cell count to normal levels, despite viral suppression. We hypothesize that variation in genes involved in extrinsic apoptosis pathways may influence interindividual immune recovery during ART. Methods: We assessed clinical-epidemiological variables and the allelic/genotypic distribution of functional single nucleotide polymorphisms in genes involved in extrinsic apoptosis pathways (TNFRSF1A: rs1800692 and rs767455; TNFAIP3: rs2270926; NFKBIA: rs8904; and TNF-α: rs1800629) and their relationship with immune recovery in ART-treated (1 year) HIV-1–infected individuals. We enrolled 155 HIV-1–infected individuals, with 102 individuals showing immunological success and 53 with immunological failure. Results: Through univariate analysis, we observed that the male sex (60.4%, P = 0.002) showed a higher median of age at treatment onset (34.8 years, P = 0.034) and higher time until virological suppression (6 months, P = 0.035), both risk factors for immune failure. Survival analysis revealed that individuals who started ART treatment with CD4+ T-cell count <200 cells/mm3 took a longer time to immunological recovery (median time = 27 months, P = 0.029). ART containing zidovudine also was associated with immune recovery in univariate e multivariate analysis. Variants in TNFRSF1A (rs767455: T and TT; rs1800692-rs767455: T-T combination) and NFKBIA (rs8904: A) genes were associated with immune failure, whereas NFKBIA (rs8904: GA) and TNF-α (rs1800629: GA) were with CD4+ T-cell recovery. Conclusions: Clinical-epidemiological variants in genes involved in extrinsic apoptosis pathways might influence the CD4+ T-cell immune recovery.pt_BR
dc.language.isoenpt_BR
dc.subjectPolimorfismo genéticopt_BR
dc.subjectApoptosept_BR
dc.subjectAntígenos CD4pt_BR
dc.titleBrief report: polymorphisms in TNF-α/TNFR1 pathway genes are associated with CD4+ T-Cell recovery in HIV-1-Infected individuals on antiretroviral therapypt_BR
dc.higia.programArtigos científicos colaboradores IMIPpt_BR
dc.higia.tipoArtigo Científicopt_BR
dc.higia.pages6 p.pt_BR
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