Use este identificador para citar ou linkar para este item: http://higia.imip.org.br/handle/123456789/872
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dc.contributor.authorFuchs, Flavio Danni-
dc.contributor.authorScala, Luiz Cesar Nazario-
dc.contributor.authorVilela-Martin, José Fernando-
dc.contributor.authorWhelton, Paul K.-
dc.contributor.authorFigueiredo, Carlos Eduardo Poli de-
dc.contributor.authorSilva, Ricardo Pereira e-
dc.contributor.authorGus, Miguel-
dc.contributor.authorBortolotto, Luiz Aparecido-
dc.contributor.authorConsolim-Colombo, Fernanda Marciano-
dc.contributor.authorSchlatter, Rosane Paixão-
dc.contributor.authorCesarino, Evandro José-
dc.contributor.authorCastro, Iran-
dc.contributor.authorFigueiredo Neto, José Albuquerque de-
dc.contributor.authorChaves, Hilton-
dc.contributor.authorSteffens, André Avelino-
dc.contributor.authorAlves, João Guilherme Bezerra-
dc.contributor.authorBrandão, Andrea Araujo-
dc.contributor.authorSousa, Marcos Roberto de-
dc.contributor.authorJardim, Paulo César Brandão Veiga-
dc.contributor.authorMoreira, Leila Beltrami-
dc.contributor.authorFranco, Roberto Jorge da Silva-
dc.contributor.authorGomes, Marco M.-
dc.contributor.authorAfiune Neto, Abrahão-
dc.contributor.authorFuchs, Felipe Costa-
dc.contributor.authorSobral Filho, Dário Celestino-
dc.contributor.authorNóbrega, Antônio C.-
dc.contributor.authorNobre, Fernando-
dc.contributor.authorBerwanger, Otávio-
dc.contributor.authorFuchs, Sandra Cristina Pereira Costa-
dc.date.accessioned2022-07-13T15:20:52Z-
dc.date.available2022-07-13T15:20:52Z-
dc.date.issued2021-
dc.identifier.urihttp://higia.imip.org.br/handle/123456789/872-
dc.description.abstractAims: To compare the blood pressure (BP)-lowering efficacy of a chlorthalidone/amiloride combination pill with losartan, during initial management of JNC 7 Stage I hypertension in patients with type 2 diabetes mellitus. Methods: In an a priori subgroup analysis of a randomized, double-blind, controlled trial, volunteers aged 30–70 years, with stage I hypertension and diabetes mellitus, were randomized to 12.5/2.5 mg of chlorthalidone/amiloride (N = 47) or 50 mg of losartan (N = 50), and followed for 18 months in 21 clinical centers. If BP remained uncontrolled after three months, study medication dose was doubled, and if uncontrolled after six months, amlodipine (5 and 10 mg) and propranolol (40 and 80 mg BID) were added as open label drugs in a progressive fashion. Results: Systolic BP decreased to a greater extent in participants allocated to diuretics compared to losartan (P < 0.001). After 18 months of follow-up, systolic BP was 128.4 ± 10.3 mmHg in the diuretic group versus 133.5 ± 8.0 in the losartan group (P < 0.01). In the diuretic group, 36 out of 43 participants (83.7%) had a JNC 7 normal BP, compared to 31/47 (66%) in the losartan group (P = 0.089). Serum cholesterol was higher in the diuretic arm at the end of the trial. Other biochemical parameters and reports of adverse events did not differ by treatment. Conclusions: Treatment of hypertension based on a combination of chlorthalidone and amiloride is more effective for BP lowering compared to losartan in patients with diabetes mellitus and hypertension.pt_BR
dc.language.isoenpt_BR
dc.subjectHipertensãopt_BR
dc.subjectDiabetes Mellituspt_BR
dc.subjectClortalidonapt_BR
dc.subjectLosartanpt_BR
dc.titleCorrection to: effectiveness of chlorthalidone/amiloride versus losartan in patients with stage I hypertension and diabetes mellitus: results from the PREVER-treatment randomized controlled trialpt_BR
dc.higia.programArtigos científicos colaboradores IMIPpt_BR
dc.higia.tipoArtigo Científicopt_BR
dc.higia.pages6 p.pt_BR
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