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dc.contributor.authorPinheiro, Marcelo Medeiros-
dc.contributor.authorPileggi, Gecilmara Cristina Salviato-
dc.contributor.authorKakehasi, Adriana Maria-
dc.contributor.authorReis, Ana Paula Monteiro Gomides-
dc.contributor.authorReis Neto, Edgard Torres dos-
dc.contributor.authorAbreu, Mirhelen Mendes-
dc.contributor.authorAlbuquerque, Cleandro Pires-
dc.contributor.authorAraújo, Nafice Costa-
dc.contributor.authorBacchiega, Ana Beatriz-
dc.contributor.authorBianchi, Dante Valdetaro-
dc.contributor.authorBica, Blanca-
dc.contributor.authorBonfa, Eloisa-
dc.contributor.authorBorba, Eduardo Ferreira-
dc.contributor.authorBrito, Danielle Christinne Soares Egypto de-
dc.contributor.authorCalderaro, Debora Cerqueira-
dc.contributor.authorDuarte, Angela Luzia Branco Pinto-
dc.contributor.authorEspírito Santo, Rafaela Cavalheiro-
dc.contributor.authorFernandes, Paula Reale-
dc.contributor.authorGuimarães, Mariana Peixoto-
dc.contributor.authorGomes, Kirla Wagner Poti-
dc.contributor.authorIlana, Gabriela Gimenez Faustino-
dc.contributor.authorKlumb, Evandro Mendes-
dc.contributor.authorMarques, Cláudia Diniz Lopes-
dc.contributor.authorMelo, Ana Karla Guedes de-
dc.contributor.authorMonticielo, Odirlei André-
dc.contributor.authorMota, Licia Maria Henrique da-
dc.contributor.authorMunhoz, Gabriela Araújo-
dc.contributor.authorPaiva, Eduardo dos Santos-
dc.contributor.authorPereira, Helena Lúcia Alves-
dc.contributor.authorProvenza, José Roberto-
dc.contributor.authorRibeiro, Sandra Lúcia Euzébio-
dc.contributor.authorRocha Junior, Laurindo Ferreira-
dc.contributor.authorSato, Emília Inoue-
dc.contributor.authorSkare, Thelma-
dc.contributor.authorSouza, Viviane Angelina de-
dc.contributor.authorValim, Valeria-
dc.contributor.authorLacerda, Marcus Vinicius Guimarães de-
dc.contributor.authorXavier, Ricardo Machado-
dc.contributor.authorFerreira, Gilda Aparecida-
dc.date.accessioned2022-07-14T18:33:00Z-
dc.date.available2022-07-14T18:33:00Z-
dc.date.issued2021-
dc.identifier.urihttp://higia.imip.org.br/handle/123456789/899-
dc.description.abstractObjective: To evaluate the incidence of COVID-19 and its main outcomes in rheumatic disease (RD) patients on hydroxychloroquine (HCQ) compared to household cohabitants (HC). Methods: This is a 24-week nationwide prospective multi-centre cohort with a control group without RD and not using HCQ. All participants were monitored through scheduled phone interviews performed by health professionals. Details regarding COVID-19 symptoms, and epidemiological, clinical, and demographic data were recorded on a specific web-based platform. COVID-19 was defined according to the Brazilian Ministry of Health criteria and classified as mild, moderate or severe. Results: A total of 9,585 participants, 5,164 (53.9%) RD patients on HCQ and 4,421 (46.1%) HC were enrolled from March 29th, 2020 to September 30th, 2020, according to the eligibility criteria. COVID-19 confirmed cases were higher in RD patients than in cohabitants [728 (14.1%) vs. 427 (9.7%), p<0.001] in a 24-week follow-up. However, there was no significant difference regarding outcomes related to moderate/ severe COVID-19 (7.1% and 7.3%, respectively, p=0.896). After multiple adjustments, risk factors associated with hospitalisation were age over 65 (HR=4.5; 95%CI 1.35-15.04, p=0.014) and cardiopathy (HR=2.57; 95%CI 1.12-5.91, p=0.026). The final survival analysis demonstrated the probability of dying in 180 days after a COVID-19 diagnosis was significantly higher in patients over 65 years (HR=20.8; 95%CI 4.5-96.1) and with 2 or more comorbidities (HR=10.8; 95%CI 1.1-107.9 and HR=24.8; 95%CI 2.5-249.3, p=0.006, respectively). Conclusion: Although RD patients have had a higher COVID-19 incidence than individuals from the same epidemiological background, the COVID-19 severity was related to traditional risk factors, particularly multiple comorbidities and age, and not to underlying RD and HCQ.pt_BR
dc.language.isoenpt_BR
dc.subjectCOVID-19pt_BR
dc.subjectSARS-CoV-2pt_BR
dc.subjectDoenças reumáticaspt_BR
dc.subjectHidroxicloroquinapt_BR
dc.titleIncidence and risk factors for moderate/severe COVID-19 in rheumatic diseases patients on hydroxychloroquine: a 24-week prospective cohortpt_BR
dc.higia.programArtigos científicos colaboradores IMIPpt_BR
dc.higia.tipoArtigo Científicopt_BR
dc.higia.pages9 p.pt_BR
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