Use este identificador para citar ou linkar para este item: http://higia.imip.org.br/handle/123456789/981
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dc.contributor.authorSampaio, Letícia Pereira de Brito-
dc.contributor.authorHenriques-Souza, Adélia Maria de Miranda-
dc.contributor.authorSilveira, Mariana Ribeiro Marcondes da-
dc.contributor.authorSeguti, Lisiane-
dc.contributor.authorSantos, Mara Lúcia Schmitz Ferreira-
dc.contributor.authorMontenegro, Maria Augusta-
dc.contributor.authorAntoniuk, Sérgio-
dc.contributor.authorManreza, Maria Luíza Giraldes de-
dc.date.accessioned2023-12-19T17:13:44Z-
dc.date.available2023-12-19T17:13:44Z-
dc.date.issued2023-
dc.identifier.urihttp://higia.imip.org.br/handle/123456789/981-
dc.description.abstractBackground  Infantile epileptic spasms syndrome (IESS) is a rare but severe condition affecting children early and is usually secondary to an identifiable brain disorder. It is related to psychomotor deterioration in childhood and epilepsy in adult life. Treatment is challenging as infantile spasms may not respond to most antiseizure medication, and relapse is frequent. Objective  To evaluate the literature regarding treatment of IESS and provide a practical guidance to a healthcare system with limited resources. Methods  An expert committee from the Brazilian Society of Child Neurology reviewed and discussed relevant scientific evidence in the treatment of IESS regarding the drugs available in Brazil. Results  Oral prednisolone and vigabatrin are the most common drugs used as first-line therapy; they are efficient and affordable therapy as both are available in the Brazilian unified health system (SUS, in the Portuguese acronym). Intramuscular adrenocorticotropic hormone (ACTH) presents similar efficacy as oral prednisolone but has a higher cost and is not available in Brazil. Other antiseizure medications such as topiramate, levetiracetam, or benzodiazepines have limited response and are prescribed as adjuvant therapy. If the health service has nutritionists, a ketogenic diet should be implemented for those not responding to hormonal and vigabatrin treatment. Epilepsy surgery is mainly indicated for patients with focal lesions that do not respond to pharmacological therapy. Conclusion  Early treatment of IESS with efficient drugs is feasible in our country. Using standard protocols increases the odds of achieving complete cessation in a shorter time and decreases relapse.pt_BR
dc.language.isoen_USpt_BR
dc.subjectEspasmos Infantispt_BR
dc.subjectEpilepsiapt_BR
dc.subjectCriançapt_BR
dc.titleBrazilian experts’ consensus on the treatment of infantile epileptic spasm syndrome in infantspt_BR
dc.higia.programArtigos científicos colaboradores IMIPpt_BR
dc.higia.tipoArtigo Científicopt_BR
dc.higia.pages13 p.pt_BR
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